Amino Acid Sequences of Two Mouse Immunoglobulin Lambda Chains
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چکیده
منابع مشابه
Amino acid sequences of two mouse immunoglobulin lambda chains.
The amino acid sequences of the lambda chains of two mouse immunoglobulins have been determined. No variations were found between these proteins. The results are compatible with earlier fingerprinting analysis of the two chains, where no differences in the tryptic peptides could be demonstrated. The lack of sequence variations could be the result either of a peculiarly restricted expression of ...
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A series of lambda+ murine hybridomas were derived from a BALB/c mouse after a single injection of anti-lambda 2 antibodies coupled to LPS. Nine lambda B cell clones (five lambda 2 and four lambda 3) were expected and seven reacted with antibodies specific for the C lambda 2 constant region but showed a particular isoelectric spectrum. Their RNA products did not hybridize with the V lambda prob...
متن کاملMouse Lambda-Chain Sequences
Amino-acid sequences of the variable regions of three lambda chains produced by plasmacytomas of BALB/c mice are compared. Two are almost certainly identical and one differs from these by three amino acids. These findings extend our earlier conclusion on the relative uniformity of sequences in this type of immunoglobulin light chain. With amino-acid sequence data on two additional lambda chains...
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Background: Immunoglobulins are a group of proteins that have important role in defense against microorganisms. Immunoglobulins consist of heavy and light chains. In human, immunoglobulin light chain comprises of two isotypes: Kappa (K) and lambda (λ) based on amino acid differences in carboxylic end of their constant region. Marked changes in the K to λ ratio can happen in monocl...
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Studies in this and in other laboratories have been concerned with the chemical composition of immunoglobulin light polypeptide chains and with the genetic significance of the chemical evidence. Many recent investigations have been devoted to the comparison of amino acid sequences of Bence-Jones proteins of manl-3 and mouse.4-6 These polypeptide chains are about 214 residues in length and consi...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1971
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.68.3.590